Vixen é baseada na personagem da DC Mari McCabe / Vixen, uma super-heroína que combate o crime, com a habilidade de conseguir reproduzir qualquer poder de qualquer animal que já habitou a Terra. Se passa no mesmo universo fictício de Arrow, Flash, e Legends of Tomorrow.
Megalyn Echikunwoke
Mari McCabe / Vixen (voice)
Stephen Amell
Oliver Queen / Green Arrow (voice)
Grant Gustin
Barry Allen / The Flash (voice)
Emily Bett Rickards
Felicity Smoak / Overwatch (voice)
Carlos Valdes
Cisco Ramon (voice)
Victor Garber
Dr. Martin Stein / Firestorm (voice)
Brandon Routh
Ray Palmer / The Atom (voice)
Katie Cassidy
Laurel Lance / Black Canary (voice)
Maria Canals-Barrera
Dr. Vargas (voice)
Trevor Devall
Drake / Jones (voice)
Neil Flynn
Chuck (voice)
Hakeem Kae-Kazim
Eshu (voice)
